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Why treat mHSPC early with ERLEADA®?

Early treatment decisions are key to pushing back on disease progression[1]

Progression from mHSPC to mCRPC could take less than 1 year[1]a
Once patients progress to mCRPC, prognosis is poor[2]
2021 EAU guidelines: do not offer ADT alone to patients whose first presentation is M1 disease and who are willing to have and eligible for combination therapy[3]
Treating mHSPC patients early with ERLEADA® + ADT is associated with a lower frequency of AR aberrations relative to placebo + ADT[4][5]

The TITAN final analysis emphasises the benefit of early, potent, AR-signalling inhibition with ERLEADA® at the time of initial ADT for mHSPC and before progression to mCRPC.[1]

  • Patients with AR aberrations at the end of treatment had worse outcomes vs. patients without[4]
  • ERLEADA® + ADT was associated with decreased frequency of AR aberrations at the end of treatment vs. placebo + ADT[4][5]

Taken together, these findings suggest that early ERLEADA® + ADT provides long-term benefits vs. placebo + ADT without increased development of AR aberrations.[4]

aIn a Phase III study including patients with mHSPC on placebo + ADT.[1]

In mHSPC, early treatment decisions are key to pushing back on disease progression[1]

What if you could delay your patients’ progression to castration resistance and extend their lives?
Treat early with ERLEADA® + ADT to prolong survival & delay progression[1]
Treating early with ERLEADA® + ADT provides an additional treatment option for mHSPC patients[1]
Treating early with ERLEADA® + ADT helps maintain QoL[1]

Abbreviations

ADT, androgen deprivation therapy. AR, androgen receptor. EAU, European Association of Urology. M1, metastasised outside the pelvis. mCRPC, metastatic castration-resistant prostate cancer. mHSPC, metastatic hormone-sensitive prostate cancer. QoL, quality of life.

CP-282954 - janeiro 2022