DARZALEX® delivers remarkable efficacy in combination with lenalidomide and dexamethasone (Rd) in relapsed/refractory patients with ≥1 prior therapy*
Prof. María-Victoria Mateos presents 4-year follow-up data for DARZALEX® + Rd in relapsed/refractory multiple myeloma (POLLUX TRIAL)
POLLUX is a randomised, open-label, active-controlled, multicentre phase 3 study comparing DARZALEX® + Rd (DRd) vs. Rd. N=569
* DVTd vs. VTd alone.
(PDF, 5.8 MB)
POLLUX: Updated analysis presented at the ASH Annual Meeting 2019
DARZALEX® + Rd provided consistently better outcomes across pre-specified patient subgroups
* DRd vs. Rd alone.
† MRD testing was performed on ficolled bone marrow aspirate samples via the clonoSEQ® assay V2.0 (Adaptive Biotechnologies, Seattle, WA) at a sensitivity threshold of 10-5 (1 cancer cell per 100,000 nucleated cells).
* DRd vs. Rd alone.
1800 mg SC
Cycle 1–2: Weekly
Cycles 3–6: Every 3 weeks
Cycles 7+: Every 4 weeks until disease progression
25 mg PO
Once daily on Days 1–21 of each cycle until disease progression
40 mg PO/IV†
Every week until disease progression
† On daratumumab infusion days, 20 mg of the dexamethasone dose was given as a pre-infusion medication and the remainder given the day after the infusion.
DRd dosing schedule
(PDF, xx KB)
Includes a first use checklist of Darzalex® SC.
Includes DARZALEX® SC handling and administration info, pre and post-injection medications, and more
Summary of study design, efficacy results and safety profile for DRd in RRMM.
DRd: DARZALEX®, lenalidomide, dexamethasone
IRR: infusion-related reaction
MRD: minimal residual disease
NR: not reached
Rd: lenalidomide, dexamethasone
RRMM: relapsed/refractory multiple myeloma
Titular da Autorização de Introdução no Mercado: Janssen-Cilag International NV, Turnhoutseweg 30, B-2340 Beerse, Bélgica.
Para mais informações deverá contactar o Representante do Titular da Autorização de Introdução no Mercado: Janssen-Cilag Farmacêutica, Lda.
Medicamento de receita médica restrita, de utilização reservada a certos meios especializados.
Antes de prescrever consulte o RCM completo.
RCM de Darzalex®, veja aqui